Protein Details: Potassium voltage-gated channel subfamily E member 3
Protein ID
ICDB_Pro_1721
Protein Name
Potassium voltage-gated channel subfamily E member 3
Gene Name
KCNE3
Organism
Homo sapiens (Human)
Length
103 amino acids
AlphaFoldDB
AF-Q9Y6H6-F1-model_v4.pdb
Function
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship
Sequence
Ligand Binding
Binding Site
Disease
Brugada Syndrome 6 and Long Qt Syndrome 6
Location
Expressed in hippocampal neurons (at protein level) (PubMed:12954870). Widely expressed with highest levels in kidney and moderate levels in small intestine.
DOI ID
10.1074/jbc.m010713200; 10.1101/gr.2596504; 10.1038/35003200; 10.1016/s0092-8674(01)00207-0; 10.1096/fj.01-0520hyp; 10.1523/jneurosci.23-22-08077.2003; 10.1002/jcp.22265; 10.1210/jc.2002-020698; 10.1212/01.wnl.0000082392.66713.e3; 10.1212/01.wnl.0000119392.29624.88; 10.1161/circep.107.748103; 10.1002/humu.20834
RefSeq
NP_005463.1; XP_016872536.1; XP_016872537.1; XP_016872538.1; XP_016872539.1; XP_016872540.1; XP_016872541.1